EcoGene

GenePage for the cmoA gene of Escherichia coli K-12

Primary Gene Name: cmoA
EcoGene Accession Number: EG14033
K-12 Gene Accession Number: ECK1871
MG1655 Gene Identifier: b1870

Non-Core

Y-synonyms

Gene Name Mnemonic: CarboxylMethOxy

Alternate Gene Symbols: yecO

Description:
tRNA cmo(5)U34 methyltransferase, SAM-dependent

Pre-Run BlastP UniProt

Protein Sequence: ------------ MW: 27776.64------247 aa ------------ Pre-Run BlastP NR+Env

Genomic Address
Left End: 1950726 ----------------- Clockwise ----------------- Right End: 1951469
Left Inter Gene Info Minute or Centisome (%) = 42.04 Right Inter Gene Info

PDF EcoMap

Curator or user-submitted Comments:

CmoA catalyzes an intermediate step(s) in tRNA(cmo5U34) and tRNA(mcmo5U34) synthesis that forms uridine-5-oxyacetic acid (cmo5U) and uridine-5-oxyacetic acid methyl ester (mcmo5U) in tRNA. The cmoA ortholog is functionally characterized in S. typhimurium. YecO is paralogous to YgdE and FtsJ. otherPDB (H. influenzae): 1IM8. Modeling of 1IM8 suggests substrate might be a benzoic acid derivative, possibly consistent with a chorismic acid requirement for the synthesis of cmo(5)U34.